Vitamin C supplementation attenuates cadmium-associated renal biochemical and oxidative alterations in Wistar Albino rats: Vitamin C attenuates Cadmium Nephrotoxicity in rats

Sarra Derbal; Abdelmalek Arabi

doi:10.62310/liab.v6i1.424

Authors

Sarra Derbal Laboratory of Animal Ecophysiology, Badji Mokhtar - Annaba University, 12, P.O.Box, 23000 Annaba, Algeria https://orcid.org/0000-0001-7310-9697
Abdelmalek Arabi Research Laboratory on Phoeniciculture "Phoenix," Kasdi Merbah University - Ouargla 30000, Algeria https://orcid.org/0009-0002-7426-0502

DOI:

https://doi.org/10.62310/liab.v6i1.424

Keywords:

Cadmium chloride, Vitamin C, Wistar Albino rats, Renal biochemistry, Oxidative status

Abstract

The present study aimed to evaluate the nephroprotective potential of vitamin C on biochemical parameters and oxidative biomarkers in rats exposed to subchronic dose of cadmium chloride (200 mg/L) for four weeks. The rats were placed in eight cages, with five rats per cage. The cages were divided into four groups: a control group, a vitamin C group with vitamin C supplementation in drinking water (1 g/L), a cadmium chloride group receiving cadmium chloride in drinking water (200 mg/L), and a combined-treatment group receiving both cadmium chloride (200 mg/L) and vitamin C (1 g/L) in drinking water (Cd-vit C). Results revealed that cadmium-exposed group had significantly lower body weight, with increased absolute and relative kidney weights, along with higher circulating levels of urea, creatinine, and uric acid. Cadmium exposure reduced glutathione content and the activities of glutathione peroxidase, catalase, and superoxide dismutase in kidneys, whereas the malondialdehyde levels increased. Cadmium chloride exposure adversely affected body weight and renal weight, along with adverse effects on renal biochemical and antioxidants parameters. However, co-supplementation with vitamin C partially attenuated these negative changes.

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